Researchers Lerner Research Institute Cleveland Clinic in the U.S. have discovered that resveratrol, a component of red wine, when combined with the drug rapamycin can have an effect suppressor of tumors on breast cancer cells that are resistant to rapamycin alone.
Research also indicates that the PTEN tumor suppressor gene contributes to the antitumor effects of resveratrol in this combination of treatments. The study results are published in the journal Cancer Letters.
The scientists, led by Charis Eng, studied the effect of the combination of resveratrol, a chemopreventive agent found in many natural compounds with rapamycin on breast cancer cells. Research shows an additive effect between the two drugs on signaling and the development of breast cancer cells.
Eng explains, "Rapamycin has been used in clinical trials as a treatment for cancer. Unfortunately, after a time, cancer cells develop resistance to rapamycin. Our findings show that resveratrol appears to mitigate the resistance drug rapamycin-induced breast cancers, at least in the laboratory. "
If these observations be maintained in clinical facilities, enjoy a glass of red wine or eating a bowl of boiled peanuts, which have a higher content of resveratrol than red wine, before treatment with rapamycin may be a prudent choice.
Rapamycin, an immunosuppressive drug used to prevent rejection of organ transplants has been taken into account for the use of antitumor activity against breast cancer. Resveratrol is a type of polyphenol that is based on the skin of grapes and is a constituent of red wine and has been considered for many uses, regardless of cellular therapies.
Despite the potential for tumor suppression, the efficacy of rapamycin with respect to inhibition differs markedly between cell lines of breast cancer. The researchers measured the effect of resveratrol and rapamycin, alone or in combination on cell growth of three lines cellular human breast cancer.
In all three cell lines tested, the presence of low concentrations of resveratrol and rapamycin was sufficient to induce an inhibition of 50 percent. Although relatively early, these observations might suggest that resveratrol is a powerful medicine to accompany traditional chemotherapy.
Carla Gallo
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